Symbiosis Control

The definition of HIV is given in the web citation below. The symbiotic control application is indicated in the PNAS publication immediately below (Chang, et al., 2003). It involves expression of a receptor on the Lactobacillus jensenii bacterium to intercept the HIV virus and prevent infection. Treating the vaginal track with this recombinant organism would protect against sexually transmitted HIV. 

Recent Papers

Chang et al 2003 symbiotic control of AIDS.

Theresa L.-Y. Chang*, Chia-Hwa Chang*, David A. Simpson*, Qiang Xu*, Patrick K. Martin*, Laurel A. Lagenaur*, Gary K. Schoolnik†‡, David D. Ho§, Sharon L. Hillier¶, Mark Holodniy_, John A. Lewicki*,**, and Peter P. Lee†** (2003). Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4. Proc. Natl Acad. Sci. (USA) 100(20): 11672-11677.

11672–11677 _ PNAS _ September 30, 2003 _ vol. 100 _ no. 20 http://www.pnas.org/cgi/content/abstract/100/20/11672

Another more recent paper:

From the Cover: Toward a live microbial microbicide for HIV: Commensal bacteria secreting an HIV fusion inhibitor peptide

Srinivas Rao, Stella Hu, Louise McHugh, Kira Lueders, Ken Henry, Qi Zhao, Richard A. Fekete, Sudeshna Kar, Sankar Adhya, and Dean H. Hamer PNAS 2005;102 11993-11998. http://www.pnas.org/cgi/content/abstract/102/34/11993?etoc